The club was founded as Blackpool Metal Mechanics in 1947 before changing their name to Blackpool Mechanics. They initially played in local leagues on the Fylde coast.
They won the Fylde District League Division Two title in the 1950–51 season and were promoted to Division One, where between 1953–54 and 1957–58 they were champions twice and runners-up three times in five consecutive seasons.
In 1959 the club took the decision move up the leagues and joined the West Lancashire League. In their first season, 1959–60, they were runners-up. In 1960–61 they were champions and also won the Lancashire FA Amateur Shield again. The following season they were again West Lancashire League champions.
In 1962, they joined the Lancashire Combination Division Two. In the 1972–73 season they won the Lancashire Combination Bridge Shield and in 1974–75 finished as runners-up in the league, just one point behind champions Darwen. With the formation of the North West Counties Football League, they were placed in Division Three, and were promoted as champions to Division Two in 1985–86.
In May 2005 Lytham St. Annes FC, who had just won the West Lancashire League Division One title, merged into the Mechanics after resigning from the West Lancashire league. In May 2008 the Mechanics merged with Squires Gate Junior FC, with the club renamed AFC Blackpool. The name change depended upon Blackpool giving it their full approval, and in July 2008 they confirmed to the Lancashire Football Association that they had no objections and that they were keen to help the club.
As champions of Division One in 2010–11, they were promoted to the Premier Division. On 21 March 2015 some Blackpool fans boycotting their match with Leeds in protest at chairman Karl Oyston's management of the club decided to attend AFC Blackpool's match against Bootle. The game saw an attendance of 503 compared with an average of 35 that season; many Leeds fans also attended the match as part of a combined general protest "against the Football League as well and the various things they have done over the past couple of years."
The club were relegated to Division One of the North West Counties League at the end of the 2015–16 season, in which they finished bottom of the table.